As a combat support agency, DTRA is responsible to the Assistant to the Secretary of Defense (Nuclear, Chemical and Biological Defense Programs), who in turn is responsible to the Under Secretary of Defense for Acquisition, Technology and Logistics.

DTRA is typically led by a senior civil servant, a member of the Senior Executive Service. DTRA also has a Deputy Director at the 2-star level, and a Command Senior Enlisted Leader, responsible for offering an enlisted perspective on operational issues and missions.

Rear Adm. Scott Jerabek
U.S. Navy
Deputy Director
  Shari Durand
Senior Executive Service
Acting Director
  Chief Master Sgt. Timothy Horn
U.S. Air Force
Command Sr. Enlisted Leader