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As a combat support agency, DTRA is responsible to the Assistant to the Secretary of Defense (Nuclear, Chemical and Biological Defense Programs), who in turn is responsible to the Under Secretary of Defense for Acquisition, Technology and Logistics.
DTRA is typically led by a senior civil servant, a member of the Senior Executive Service (SES). DTRA also has a Deputy Director for Combat Support, a Vice Director for Mission Integration, a Vice Director for Plans & Programs, and a Command Senior Enlisted Leader, responsible for offering an enlisted perspective on operational issues and missions.